Scientific collaboration using cyberinfrastructure (CI), or e-Science, is forward facing. e-Science projects aim to support the collaboration of research communities, whether by facilitating distanced collaboration or sharing data and computational resources. The most ambitious e-Science projects are creating entirely novel scientific fields, anticipating and actively cultivating new scientific communities and practices. Such endeavors present original challenges to researchers in CSCW fields: questions of large-scale technology development, of supporting communities in addition to groups, and of long-term sustainability.